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琳恩·伊丽莎白·马卡特1952—

Lynne E. Maquat

American biochemist

沃尔夫医学奖 2021

Lynne Elizabeth Maquat is an American biochemist and molecular biologist whose research focuses on the cellular mechanisms of human disease. She is known for her work in describing the process of nonsense-mediated decay. She is an elected member of the American Academy of Arts and Sciences, the National Academy of Sciences and the National Academy of Medicine. She currently holds the J. Lowell Orbison Endowed Chair and is a professor of biochemistry and biophysics, pediatrics and oncology at the University of Rochester Medical Center.

摘自英文维基百科「Lynne E. Maquat」（英文维基百科，暂无中文条目），CC BY-SA 4.0

英文维基百科 Wikidata

出生: 1952 年
国籍: 美国
学科: 化学、生物学
职业: 大学教师、生物化学家
母语 / 工作语言: 英语
母校: 威斯康星大学麦迪逊分校（哲学博士，1979 年）、康涅狄格大学（文学士，1974 年）
工作单位: 罗切斯特大学

研究领域

生物化学

所获奖项（9）

2006美国科学促进会会士
2014William C. Rose Award
2015盖尔德纳国际奖
2017Vanderbilt Prize in Biomedical Science
2018FASEB Excellence in Science Award
2018威利奖
2021沃尔夫医学奖
2021华伦阿尔波特奖
2023格鲁伯遗传学奖

学会与院士

美国国家科学院美国文理科学院Graduate Women in Science

百科正文

本条目暂无中文维基百科条目，下面是英文维基百科原文。

Education

Maquat graduated magna cum laude with a Bachelor of Science degree in biology from the University of Connecticut in 1974. She received her PhD in biochemistry from the University of Wisconsin-Madison in 1979.

Career and research

Maquat did postdoctoral research at the McArdle Laboratory for Cancer Research in Madison, Wisconsin. She then had a brief stint at Roswell Park Comprehensive Cancer Center in Buffalo, New York before settling at the University of Rochester in Rochester, New York, where she now holds an endowed chair. Her research is focused on mRNA decay and the molecular basis of human disease. Her research Specifically, she was the first to describe nonsense-mediated mRNA decay, work that enabled the discovery of the exon junction complex as a critical quality-control mechanism in the cell. She also described Staufen-mediated mRNA decay, a competitive process to NMD, and microRNA degradation. Her research began with beta thalassemia as a model and expanded to other hemoglobinopathies. She has also studied cell death in breast cancer cells exposed to chemotherapy, and cellular differentiation in muscle cells. Maquat also founded the Graduate Women in Science program at the University of Rochester Medical School, which provides mentoring and support to women seeking graduate education in the sciences.

Elected fellowships/memberships

2006 American Association for the Advancement of Science
2006 American Academy of Arts and Sciences
2011 National Academy of Sciences
2018 National Academy of Medicine

Awards and honors

2010 Lifetime Achievement Award in Service from the International RNA Society
2012–2013 Batsheva de Rothschild Fellow of the Israel Academy of Sciences and Humanities
2014 Athena Award for community involvement
2014 William C. Rose Award
2015 Canada Gairdner International Award
2017 Vanderbilt Prize in Biomedical Science
2017 Lifetime Achievement Award in Science from the International RNA Society

2018 FASEB Excellence in Science Award.

2018 Wiley Prize in Biomedical Sciences, Rockefeller University, New York, NY
2019 IUBMB Jubilee Lectureship
2021 Wolf Prize in Medicine, Wolf Foundation, Israel
2021 Warren Alpert Foundation Prize Harvard Medical School, Boston, Massachusetts
2023 Gruber Prize in Genetics
2024 Dr. Paul Janssen Award for Biomedical Research
2024 Albany Medical Center Prize in Medicine and Biomedical Research

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