迈克尔·塞拉1924—2022

经历

塞拉在魏茨曼研究所跟伊弗雷姆·卡齐尔研究，在那里他获得了博士学位。作为一个学生毕业后，他曾与克里斯蒂安·安芬森在美国国立卫生研究院工作。他在1957年回到魏茨曼研究所，成为免疫学教授。1963年至1975年，他是免疫学教研室主任。1970年至1973年任生物部主任。1975年至1985年任所长。2022年5月27日逝世。

奖项和荣誉

1980年获盖尔德纳国际奖，1998年获沃尔夫医学奖。

Michael Sela (Hebrew: מיכאל סלע; Mieczysław Salomonowicz; 2 March 1924 – 27 May 2022) was an Israeli immunologist of Polish Jewish origin. He was a president of Weizmann Institute of Science in Rehovot.

Early life and academic career

Michael Sela was born as Mieczysław Salomonowicz in Tomaszów Mazowiecki, Poland, on 2 March 1924. In 1935 when he was 11 years old he and his family moved to Romania. In 1941 when he was 17 years old he and his family immigrated to Mandatory Palestine. He studied at the Hebrew University of Jerusalem (M.Sc., Chemistry, 1946; Ph.D., 1954).

Sela was professor in the Weizmann Institute's Immunology Department. He was also a president of the Weizmann Institute of Science, from 1975 to 1985. He died in Rehovot on 27 May 2022 at the age of 98.

Research

Sela is known for his research in immunology, particularly for research on synthetic antigens, molecules that trigger the immune system to attack. This work of Sela has led to the discovery of the genetic control of the immune response, as well as to the design of vaccines based on synthetic molecules.

He was among the first who introduced the use of linear and branched synthetic polypeptides as antigens, and this brought about a better understanding of immunological phenomena.

For several decades, Sela was interested in the possibility of fighting the autoimmune disease, experimental allergic encephalomyelitis with synthetic analogs of the molecules in the myelin sheath of the brain which are capable of provoking the disease.

He is probably best known as the co-developer (with Ruth Arnon and Dvora Teitelbaum) of the multiple sclerosis drug copaxone.

Awards and honours

• Sela received numerous major national and international awards:
• The Israel Prize in Life Sciences (1959)
• Germany's Otto Warburg Medal (1968)
• The Rothschild Prize (1967)
• Member of the American Academy of Arts and Sciences (1971)
• Germany's Emil von Behring Prize (1972)
• Member of the National Academy of Sciences of the United States (1976)
• Canada's Gairdner Foundation International Award (1980)
• France's Institut de la Vie Prize (1984)
• Germany's Commander's Cross of the Order of Merit Award (1986)
• France's Officier de l'Ordre de la Légion d'honneur (1987)
• Member (Hon. causa) of The Romanian Academy (Academia Română) (1991)
• UNESCO's Albert Einstein Golden Medal (1995)
• Member of the American Philosophical Society (1995)
• Interbrew-Baillet Latour Health Prize of Belgium (1997)

The Wolf Prize in Medicine (1998), along with Ruth Arnon, for "their major discoveries in the field of immunology".