纳胡姆·索嫩贝尔格1946—

学术研究

索嫩贝尔格确定了eIF4E-蛋白质，它是的mRNA的5'端帽结构的一部分，并发现IRES在真核生物翻译起始机制，eIF4E的结合蛋白（4E-BP）的翻译的帽依赖性调节。通过索嫩贝尔格和同事对4E-BP基因敲除小鼠的研究表明，eIF4E在学习和记忆过程中起着重要的作用。索嫩贝尔格的其他工作包括对脊髓灰质炎病毒、鼻病毒、人类免疫缺陷病毒（HIV）的研究。

奖项和荣誉

2006年被选为皇家学会会员，2008年获盖尔德纳国际奖，2014年获沃尔夫医学奖。

Nahum Sonenberg, (Hebrew: נחום סוננברג; born December 29, 1946) is an Israeli Canadian microbiologist and biochemist. He is a James McGill professor of biochemistry at McGill University in Montreal, Quebec, Canada. He was an HHMI international research scholar from 1997 to 2011 and is now a senior international research scholar.

Education

Sonenberg was born in a camp for displaced persons in Wetzlar, Germany and grew up in Israel. He received a B.Sc. and M.Sc. in microbiology and immunology from Tel Aviv University and his Ph.D. in biochemistry from the Weizmann Institute of Science in 1976. He later held a Chaim Weizmann postdoctoral fellowship at the Roche Institute of Molecular Biology. He joined McGill University in 1979.

Research

Sonenberg's primary research has been on the translational control of protein synthesis. Sonenberg also discovered the Internal ribosome entry site (IRES) mode of translation, the cap-independent initiation of translation, which is critical for some mRNA involved in stress, cell cycling and apoptosis. Currently, he has expanded his research into topics such as the roles of translation in neurobiology and synaptic plasticity. Presently, his lab works on translational control in cancer, oncolytic viruses as anti-cancer drugs, microRNA control of translation, and translational control of plasticity, learning and memory. He received the Gairdner Foundation International Award in 2008 for his contributions to medical science. He was appointed an Officer of the Order of Canada in 2010.

In 2014, Sonenberg was awarded the Wolf Prize in Medicine.

Awards and recognition

Recipient of the Robert L. Noble Prize from the National Cancer Institute of Canada in 2002

• Recipient of the Isaak-Walton-Killam Award for Health Sciences in 2005
• Elected a Fellow of the Royal Society in 2006
• Recipient of the Gairdner Foundation International Award in 2008
• Appointed as an Officer of the Order of Canada in 2010
• Recipient of the Lewis S. Rosenstiel Award in 2011
• Named Fellow of the American Association for the Advancement of Science in 2012
• Recipient of the Royal Society of Canada McLaughlin Medal in 2013
• Recipient of the Wolf Prize in 2014
• Elected Foreign Associate, US National Academy of Sciences in 2015