安东尼·R·亨特1943—

生平

他从英国剑桥大学获得了博士学位。从1971年到1973年，他是加利福尼亚州拉霍亚索尔克研究所的研究助理。他于1975-78任助理教授，1978年至1982年任副教授，1982年起任教授，自2008年以来任索尔克研究所的癌症中心主任。

他的主要成就是发现酪氨酸磷酸化是一个基本的跨膜信号转导机制，以响应生长因子刺激，以及活化的致癌蛋白酪氨酸激酶可导致酪氨酸磷酸化的失调，这是细胞的恶性转化的一个重要机制。

Anthony Rex Hunter (born 23 August 1943) is a British-American biologist who is a professor of biology at the Salk Institute for Biological Studies and the University of California San Diego. His research publications list his name as Tony Hunter.

Professor Hunter is an elected member of the UK's Royal Society and the USA's National Academy of Sciences.

Early life and education

Hunter was born in 1943 in the United Kingdom and educated at Felsted School, prior to Christ's College, Cambridge, where he was awarded a PhD in 1969 for research on protein synthesis.

Career and research

Following his PhD, Hunter held a fellowship at Christ's College, Cambridge, in Cambridge (1968–1971) and (1973–1975). From 1971 to 1973, he was a postdoctoral research associate of the Salk Institute for Biological Studies in La Jolla, California. He was then assistant professor 1975–78, associate professor 1978–82, professor 1982 onwards and since 2008 director of the Salk Institute Cancer Center. He also sits on the Selection Committee for Life Science and Medicine which chooses winners of the Shaw Prize.

Hunter is one of the foremost recognized leaders in the field of cell growth control, growth factor receptors and their signal transduction pathways. He is well known for discovering that tyrosine phosphorylation is a fundamental mechanism for transmembrane-signal transduction in response to growth factor stimulation and that disregulation of such tyrosine phosphorylation, by activated oncogenic protein tyrosine kinases, is a pivotal mechanism utilized in the malignant transformation of cells. His work is important in signaling pathways and their disorders.

Hunter was a founder of Signal Pharmaceuticals.

Awards and honors

He won the Wolf Prize in Medicine in 2005 for "the discovery of protein kinases that phosphorylate tyrosine residues in proteins, critical for the regulation of a wide variety of cellular events, including malignant transformation". He has been granted along with Charles Sawyers and Joseph Schlessinger with the 2014 BBVA Foundation Frontiers of Knowledge Award in the Biomedicine category for "carving out the path that led to the development of a new class of successful cancer drugs".

1987 Fellow of the Royal Society (FRS)

1994 Charles S. Mott Prize by the General Motors Cancer Research Foundation.

1994 Gairdner Foundation International Award.

1998 Member of the US National Academy of Sciences.

2001 Keio Medical Science Prize

2004 Louisa Gross Horwitz Prize from Columbia University.

2005 Wolf Prize in Medicine

2006 Pasarow Award in Cancer Research.

• 2014 Royal Medal
• 2014 BBVA Foundation Frontiers of Knowledge Award in Biomedicine
• 2017 Sjöberg Prize for Cancer Research
• 2018 Tang Prize
• 2018 Pezcoller Foundation-AACR International Award for Cancer Research
• 2026 Albany Medical Center Prize